second primary head and neck cancer

AU - Samuels, Michael A. Re-treatment is associated with an increased risk of serious toxicity and impaired quality of life (QOL) with an uncertain survival advantage. Patients 4, 6, 12, and 15 developed lung lesions long after initial therapy for HNSCC but soon after locoregional recurrence. Regular dental exams may also be necessary. J Oral Pathol Med . PURPOSE: Phase II trial to study the effectiveness of photodynamic therapy for palliative treatment in patients who have recurrent, refractory, or second primary head and neck cancer that cannot be treated with surgery or radiation therapy. These patients have a high risk of developing other cancers simultaneously or subsequently. The most common second primary sites were head and neck district and lung (70, 31.5% and 67, 30.2%, respectively). Purpose The purpose of the present study was to determine the rate of second primary head and neck cancer development among patients with a primary cancer diagnosed outside the head and neck region, to present the clinical characteristics of this population, and to determine whether any variables are associated with survival. Background. The incidence of multiple primary tumors in this population can be as high as 27%. Crossref Patients and healthcare providers must strongly consider and have a high clinical suspicion of the potential influence of SPMs on survival. However, some of the head and neck cancer(HNC) patients had the poor survival rate because of development of second primary tumors. Two of the 59 patients who used cannabis, 3.4 per cent, developed a second primary cancer compared to 23 of the 454 patients, 5.1 per cent, of the controls. METHODS: A 1:1 matched pair design and a stratified Cox proportional hazard … Recently, computed tomography (CT) of the chest was shown to significantly decrease the risk of death due to bronchial carcinoma (BC) in a cohort of smokers whose risk of BC is increased but might be lower than that of patients previously … The expression of p53 protein in primary head and neck squamous cell carcinoma was significantly predictive of shorter survival because of its association with earlier development of both tumor recurrence and second primary tumors. Diaz DA, Reis IM, Weed DT, et al. Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). AU - Elsayyad, Nagy. Rennemo E, Zätterström U, Boysen M: Synchronous second primary tumors in 2,016 head and neck cancer patients: role of symptom-directed panendoscopy. Second primary lung cancer (SPLC) is generally of poor prognosis in patients presenting with head and neck cancer. 1 Approximately one third of HNSCC deaths are attributable to SPMs, 2,3 triple the number of deaths that are a result of distant metastases. Laryngoscope. Int J Radial Oncol Biol Phys 1989 ; 17: 467 –76. The incidence of second primary cancer was very high in persons who had been heavy smokers and/or heavy drinkers before the occurrence of their primary cancer in the head and neck region. Head Neck 2016; 38 Suppl 1:E873. Both of the cannabis users and six of the controls who developed an SPC were active cigarette smokers, the study states. Head and neck second primary cancer rates in the human papillomavirus era: A population-based analysis. With Hodgkin disease, the treatment of the disease which is often at a young age combined with a high survival rate is associated with a high risk of secondary cancers. Patients and Methods We designed a case series … “Eleven of the 17 non-cigarette smokers who developed an SPC were ex-cigarette smokers.” Two of the … 2011, 121 (2): 304-309. A meta-analysis was performed on data from 25 studies reporting synchronous and metachronous second malignancies in head and neck cancer. Recurrences are the most common cause of treatment failure within the first 2 years of follow-up. Condition or disease Intervention/treatment Phase ; Head and Neck Cancer… Warnakulasuriya KAAS, Robinson D, Evans H. Multiple primary tumours following head and neck cancer in southern England during 1961–98. Background: Local and/or regional recurrence and metachronous primary tumor arising in a previously irradiated area are rather frequent events in patients with head and neck squamous cell carcinoma (HNSCC). 10.1002/lary.21385. 1989 Sep;17(3):467-76.) Treatment of local and locoregional recurrence or second head-and-neck (H&N) cancers after previous radiotherapy remains a challenge due to an increased risk of radiotherapy-related normal tissue toxicities and tumor radioresistance [].It has been reported that up to 30% of patients receiving definitive chemoradiotherapy for unresectable H&N cancer develop … While the constant long-term risk for the head and neck cancer patient has been well established, efforts at prevention, early detection, and treatment have been somewhat futile. Second Primary Tumors in Head & Neck. With improvements in locoregional control, the problem of second primary malignancies is rapidly being pushed to the forefront of head and neck oncology. Head and neck cancer is often associated with second primary neoplasms, the incidence varying from 5% to 30%. Last Revised: June 9, 2020 AU - Abramowitz, Matthew C. PY - 2015. 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